The Unwanted Guest: Parasites are clever about overstaying their welcome, co-evolving with their unwilling hosts to…

The Unwanted Guest: Parasites are clever about overstaying their welcome, co-evolving with their unwilling hosts to survive and propagate. Viruses, for example, insert their DNA into the host chromosome, ensuring that they are passed on to the daughter cells.

This clever protozoan, Theileria (in green), aligns itself with the mitotic spindle (shown in red) as if it were a chromosome. When the spindle of the dividing host cell pulls apart to form two nuclei (in blue), the parasite goes along for the ride. Theileria  infects cattle via tick bites and resides in white blood cells. Other disease causing protozoan parasites like Plasmodium and Toxoplasma also co-opt microtubules to help in cell invasion. This new finding means that drugs that target microtubules could block parasite spread.

Free Read: http://goo.gl/NM4uv

Image from Dirk Dobbelaere, University of Bern (Switzerland) via BPoD.

#sciencesunday  

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26 Responses to The Unwanted Guest: Parasites are clever about overstaying their welcome, co-evolving with their unwilling hosts to…

  1. Rajini Rao says:


    ZOMG, that is seriously creepy! I think Buddhini Samarasinghe has posted on zombie parasites before.

  2. Rajini Rao says:


    Happy ending, as Buddhini says, “the only good cockroach is a dead cockroach” 🙂

  3. Rajini Rao says:


    It’s all for science, Do it! 😀

  4. Rajini Rao says:


    As often happens, it’s the image that captures the imagination first, Malin Christersson 🙂


  5. Clever Theileria!  It seems awfully tiny for a protozoan (size of a chromosome?), so I did an image search on google and found the most interesting images, mostly of ticks, and one of a chromosome being hijacked – “The New Scientist”  http://www.the-scientist.com/?articles.view/articleNo/30719/title/Mitotic-Hijacker/


  6. G+ is all about visualization, which sometimes is unfortunate in my humble opinion. 😀

  7. Rajini Rao says:


    That’s a great read, thanks for the link BiologyCorner ! It was nice to get the author’s perspective on the work.


    Theileria is described as a syncytium in this stage of its life cycle..sort of amoeba like, I imagine. It’s interesting that it does not interfere with chromosome segregation, or host cell mitosis.

  8. raj rajak says:


    hello how r u rajni  09907421220 coll plz i mis you 

  9. Rajini Rao says:


    LOL, Feisal Kamil , I’m afraid to try it 🙂


    And thanks, you’re a great pal.

  10. Chad Haney says:


    Raj, I’ll help you out, here’s a toll free number that will connect you. 1-888-642-6257

  11. Chad Haney says:


    Rajini Rao you post is called unwanted guest hehe.

  12. Rajini Rao says:


    It was an unwitting invitation, wasn’t it Chad Haney ? 😀


    I think we have dislodged his invasion, though, thanks for your help!

  13. Euro Maestro says:


    Great post Rajini Rao 

  14. Euro Maestro says:


    Lacerant Plainer gmta ! 

  15. Mary T says:


    Great post, and always such awesome wit amongst the scientists, :).


  16. Hehe yep Euro Maestro 🙂 I see our comments were a minute apart, but it took time for yours to be visible to me.

  17. Shawn Huston says:


    That is fascinating; I love science stuff like this. An to think we still only know about 70 percent (if that) of what the small world has to offer.

  18. pinto xavier says:


    how this  is  imaged and  observed ?? what   techniqued


    ?

  19. Rajini Rao says:


    pinto xavier , this is standard immunofluorescence microscopy using antibodies and DAPI for the nuclear stain. They used confocal imaging, where fluorescence is collected from a thin optical section to make the image sharper. The details are in the methods section of the PLoS Biology paper in the link that I provided.

  20. Arnav Kalra says:


    The image looks awesome. I guess the host does not think so.

  21. J Stasko says:


    Does this imply common, already investigated drugs, such as colchicine?

  22. Rajini Rao says:


    Yes, I agree. Several anti-cancer drugs target microtubules, including colchicine and vinblastine.

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