BrainCloud A stunningly comprehensive catalog of gene expression in the human brain, ranging from prenatal to adult,…

BrainCloud A stunningly comprehensive catalog of gene expression in the human brain, ranging from prenatal to adult, across gender and ethnicity. Two publications in this week’s Nature from research at Yale and Johns Hopkins chart the specific turning off and on of genes during development. A wave of gene expression changes occur in the fetus, which is reversed after birth. 50 years later, a similar reversal occurs, mirroring ageing and neurodegeneration. Gender differences were found not only in which genes were on/off, but also in choice of exons (i.e., the gene products were different). Although there were millions of genetic differences between individuals and across races, the molecular architecture was basically the same. Remarkably, 86% of 17,565 genes surveyed were expressed at some time or place in our brains.

All this information will be freely available through BrainCloud, in a “biologist-friendly” format. http://www.niseweb.com/wordpress/

See also: http://www.sciencedaily.com/releases/2011/10/111028121759.htm

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7 Responses to BrainCloud A stunningly comprehensive catalog of gene expression in the human brain, ranging from prenatal to adult,…


  1. Thank you for sharing. I wish I had enough time to make online version of this with HTML5.

  2. Matt Kuenzel says:


    We discover a wave of gene expression changes occurring during fetal development which are reversed in early postnatal life. One half-century later in life, this pattern of reversals is mirrored in aging and in neurodegeneration.


    Booo!

  3. Rajini Rao says:


    LOL, Matt Kuenzel , I just summed this story up to my husband and he said he did not want to hear anymore. 😀

  4. Matt Kuenzel says:


    Rajini Rao Ha ha ha, I know how he feels!

  5. Rajini Rao says:


    Sarkis Dallakian, Ph.D. , let me know if you do, I would be interested in looking at it.

  6. Matt Kuenzel says:


    Sarkis Dallakian, Ph.D. Yes, please let me know also, that would be great, I imagine the app will require a typically painful install process.


  7. Matt Kuenzel Sure. I’m waiting to see what will happen to Google Body. If they would open source part of it, as they promised, it would make it easier to write apps like this.

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