BrainCloud A stunningly comprehensive catalog of gene expression in the human brain, ranging from prenatal to adult, across gender and ethnicity. Two publications in this week’s Nature from research at Yale and Johns Hopkins chart the specific turning off and on of genes during development. A wave of gene expression changes occur in the fetus, which is reversed after birth. 50 years later, a similar reversal occurs, mirroring ageing and neurodegeneration. Gender differences were found not only in which genes were on/off, but also in choice of exons (i.e., the gene products were different). Although there were millions of genetic differences between individuals and across races, the molecular architecture was basically the same. Remarkably, 86% of 17,565 genes surveyed were expressed at some time or place in our brains.
All this information will be freely available through BrainCloud, in a “biologist-friendly” format. http://www.niseweb.com/wordpress/