Ion channels rapidly move charges in/out of cells to trigger sensations..including pain. Anesthetics work because they target ion channels. The news article below links chronic pain sensing (nociception) to one type of channel (hyperpolarization-activated cyclic nucleotide-gated potassium channel isoform 2, mercifully abbreviated to HCN2). Truth in advertising: you should know that this is only one of many such ion channels. ..here is an old link to an interesting story about people who have a mutation in a type of sodium channel and can no longer feel pain..they can walk on coals, for example. Sadly, this is not a good thing..the young boy in the article died early from risky behavior.
Originally shared by ****
For the first time in human history…a major scientific breakthrough promises to provide relief for the millions who suffer from chronic pain